Product Name :
MyD88 Recombinant Rabbit Monoclonal Antibody [PSH05-58]
Predicted band size :
33 kDa
Observed band size :
33 kDa
Synonyms:
Mutant myeloid differentiation primary response 88 antibody MYD 88 antibody Myd88 antibody MYD88_HUMAN antibody MYD88D antibody Myeloid differentiation marker 88 antibody Myeloid differentiation primary response 88 antibody Myeloid differentiation primary response gene (88) antibody Myeloid differentiation primary response gene 88 antibody Myeloid differentiation primary response gene antibody 展开
Function :
Interleukin-1 (IL-1)-induced activation of the NFκB pathway is mediated through the IL-1 receptor and the subsequent phosphorylation of IL-1 receptor-associated kinase (IRAK). The myeloid differentiation protein MyD88 was originally characterized as a protein upregulated in myeloleukemic cells following IL-6-induced growth arrest and terminal differentiation. MyD88 is now known to function as an adaptor protein for the association of IRAK with the IL-1 receptor. MyD88 is functionally homologous to the adaptor protein tube in the Toll signaling pathway of Drosophilia, and both proteins are members of the Toll/IL-1R superfamily. MyD88 contains a characteristic N-terminal death domain that is essential for NFκB activation and an adjacent Toll/IL-1R homology domain (TIR domain). Collectively, these domains enable the protein-protein interactions of MyD88 with IRAK and the IL-1 receptor complex.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within human MyD88 aa 101-296 / 296.
Species reactivity:
Human, Monkey
Verify application:
WB, IF-Cell, IHC-P, FC, IP
Coupling :
unconjugated
Clone number:
PSH05-58
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Methyl 5-bromo-1H-indole-4-carboxylate In stock Aliquot store at -20℃.1363210-41-6 web Avoid repeated freeze / thaw cycles.PMID:33683533
Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 33 kDa
Positive control :
A549 cell lysate, HepG2 cell lysate, MCF7 cell lysate, Jurkat cell lysate, K-562 cell lysate, HL-60 cell lysate, LNCaP cell lysate, SK-Br-3 cell lysate, COS-1 cell lysate, A549, human kidney tissue, human lung cancer tissue.