Tal HDL-c (A), huge HDL-c (B), modest HDL-c (C), waist circumference (D), VEGF (E), uric acid (F), adiponectin (G), TNF- (H) and hsCRP (I), in pre and postmenopausal diabetic individuals and controls. Results are presented as mean ?SEM. *p0.05, **p0.01 and ***p0.001.Markers of inflammation, angiogenesis and endothelial lesionThe diabetic females presented improved levels of serum VEGF, uric acid, hsCRP and TNF- and reduced of adiponectin, when compared with the handle females, whilst male diabetic individuals showed elevated serum uric acid and hsCRP concentrations and reduced TNF- and adiponectin, when compared with male control subjects (Figure 1E, 1F, 1G, 1H and 1I). Regarding differences in between male and female, diabetic womenpresented considerably improved levels of serum VEGF, hsCRP and adiponectin (versus male patients), while manage females presented drastically lowered values of uric acid, TNF- and adiponectin, when compared with male controls (Figure 1F, 1G, 1H and 1I). Concerning menopause influence, postmenopausal diabetic individuals presented significantly increased serum uric acid, hsCRP, TNF- and VEGF contents, and unchanged of adiponectin, when compared with the postmenopausal controls. Premenopausal sufferers presentedMascarenhas-Melo et al. Cardiovascular Diabetology 2013, 12:61 http://cardiab/content/12/1/Page 8 ofsignificantly greater uric acid, hsCRP and VEGF concentrations, and unchanged of TNF- and adiponectin, versus the premenopausal controls (Figure 2E, 2F, 2G, 2H and 2I).Fipronil sulfide uses With regards to differences prior to and right after menopause, control postmenopausal subjects only presented elevated serum hsCRP contents, versus premenopausal control women, even though diabetic postmenopausal sufferers showed enhanced TNF- and reduced hsCRP contents (Figure 2E, 2F, 2G, 2H and 2I).Analysis of correlations amongst markers of CV risk in diabetic patientsThe values of waist circumference inside the diabetic female population had been positively and considerably correlated with TNF- (r=0.340, p=0.040), VEGF (r=0.414, p=0.011), hsCRP (r=0.448, p=0.022) levels, whilst inside the male diabetic population none of these correlations have been statistically considerable along with the associations of WC with VEGF and with hsCRP showed an inverse profile (r=0.Buy4-bromopyrimidine hydrobromide 264, p=0.105; r=-0.227, p=0.164 and r=-0.222, p=0.408, respectively) (Figure 3A, 3B and 3C). On the other hand, waist circumference was positively and significantly correlated with uric acid in males (r=0.339, p=0.035) but not in females (r=0.250, p=0.261) (Figure 3D). Furthermore, also in the female diabetic subjects, serum TNF- concentrations showed a good and significant correlation withVEGF (r=0.PMID:23558135 282, p=0.044) levels and hsCRP contents, which presented an inverse and important correlation with adiponectin (r=-0.590, p=0.004) concentrations, which were significantly less evident and statistically non-significant within the male diabetic sufferers (r=-0.027, p=0.853; r=-0.164, p=0.490) (Figure 3E and 3F). Concerning the postmenopausal diabetic population, as soon as again, there was a sturdy good and considerable correlation amongst WC and TNF- (r=0.354, p=0.046), WC and VEGF (r=0.446, p=0.014) and WC and hsCRP (r=0.496, p=0.019) levels (Figure 4A, 4B and 4B). Serum uric acid presented an inverse and significant correlation with big HDL-c (r=-0.405, p=0.045) (Figure 4D). In addition, within the similar population of postmenopausal diabetic patients, serum TNF- concentrations showed a optimistic and considerable correlation with VEGF (r=0.302, p=0.040) levels.
